THE BIO-AVAILABILITY, THE METABOLISM, AND THE DOSAGE FOR VIAGRA

The chemistry of Viagra drug reveals that it is readily absorbed in the human blood stream, with the maximum time observed for concentration ranging anywhere between 30 minutes to 120 minutes from oral dosage. Further information also reveals that Viagra is approximately 40 percent bio available, and has a high protein content of 96 percent. It is thus advised that Viagra intake must be accompanied with a rich calorie diet containing high fat and protein contents. Viagra when taken with a low fat meal has shown a reduced absorption rate.As for the metabolism rate, the half life and excretion rate from the use of Viagra, studies to this respect have found that metabolization activity for Viagra generally takes place through an enzyme known as CYP3A4 and to a lesser extent through another enzyme CYPC229 respectively. Once taken the Viagra breaks down and is excreted in the feces (80 percent), and through the urine approximately 13 percent. As for the known half-life of Viagra, this has been found to be approximately 4 hours.Another important aspect on the intake and use of Viagra is that individuals on medications for either kidney problems, liver problems or even undergoing a dialysis for kidney, the dosage for Viagra should be strictly followed under the specific instructions of the consulting physician, as these conditions are more than likely to be affected from the use of Viagra. The dosage for Viagra, like any drug, must also be seriously taken into account, as the dosage may be different for each individual, which may vary according to the unique health status, as well as the response of the individual's various organs to the intake of Viagra.The generally prescribed dosage for Viagra is 50mg taken about 1 hour prior to anticipated sexual activity. The labeling of the Viagra however states that Viagra can be taken anytime from one half hour to 4 hours prior to sexual activity.